奚宇

出生年月：1989年5月

最高学历学位：博士

职称：讲师

电子邮箱：xiyu@btbu.edu.cn

个人简历

教育经历：

2011.09-2017.06 中国农业大学 食品科学 博士(硕博连读)

2007.09-2011.06 吉林农业大学 食品科学与工程 本科

工作经历：

2017.12-2020.11 浙江大学医学院  博士后/助理研究员

2020.11-2022.9 HG0086皇冠  博士后

2022.9-至今 HG0086皇冠  讲师

主要研究领域

重金属诱导神经毒性及神经退行性疾病的分子机制研究

食源性功能因子在神经退行性疾病中的干预作用及分子机制研究

食品功能性评价与开发

主要学术成果（课题、论文、获奖、专利等）

承担的主要科研项目（限5项）：

（1）国家自然科学基金青年科学基金项，SERPINA3N介导的神经炎性反应在 TMT 神经毒性中的作用与分子机理，21万元，在研，主持

（2）教育部电磁辐射医学防护重点实验室开放课，NFκB、AMPKs等信号通路在TMT致神经元损伤中的作用研究，7万元，已结题，主持

发表的代表性论文（限10篇）：

1. Xi Y, Liu M, Xu S, Hong H, Chen M, Tian L, Xie J, Deng P, Zhou C, Zhang L, He M, Chen C, Lu Y, Reiter RJ, Yu Z, Pi H*, Zhou Z*. Inhibition of SERPINA3N-dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride-induced neurotoxicity. Journal of Pineal Research (2019): e12596, doi: 10.1111/jpi.12596. (IF=15.1)

2. Pi H#, Liu M#, Xi Y#, Chen M, Tian L, Xie J, Chen M, Wang Z, Yang M, Yu Z, Zhou Z, Gao F. Long-term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy-lysosomal machinery. FASEB Journal (2019): 2019 Jul 31:fj201900812R. doi: 10.1096/fj.201900812R. (IF=5.5)

3. Xi Y, Li H, Yu M, Li X, Li Y, Hui B, Zeng X, Wang J* and Li J*, Protective Effects of Chlorogenic Acid on Trimethyltin Chloride-Induced Neurobehavioral Dysfunctions in Mice Relying on Gut Microbiota, Food & Function, (2022), DOI: 10.1039/D1FO03334D. (IF=5.5)

4. Xi Y, Li Q, Yan J, Baldwin E, Plotto A, Rosskopf E, Hong JC, Zuo J, Bai J* and Li J*, Effects of Harvest Maturity, Refrigeration and Blanching Treatments on the Volatile Profiles of Ripe "Tasti-Lee" Tomatoes, Foods, (2021), 10. (IF=4.3)

5. Xi Y, Fan X, Zhao H, Li X, Cao J, Jiang W, Postharvest fruit quality and antioxidant of nectarine fruit as influenced by chlorogenic acid. LWT - Food Science and Technology (2016) 75: 537-544, doi: 10.1016/j.lwt.2016.10.004. (IF=5.3)

6. Xi Y, Cheng D, Zeng X, Cao J, Jiang W, Evidences for chlorogenic acid—a major endogenous polyphenol Involved in Regulation of Ripening and Senescence of apple fruit. Plos ONE (2016) 11: e0146940, doi:10.1371/journal.pone.0146940. (IF=3.8)

7. Xi Y, Jiao W, Cao J, Jiang W. Effects of chlorogenic acid on capacity of free radicals scavenging and proteomic changes in postharvest fruit of nectarine. PLoS ONE, (2017) 12: e0182494, doi: 10.1371/journal.pone.0182494. (IF=3.8)

8. Liu M#, Pi H#, Xi Y, Wang L, Tian L, Chen M, Xie J, Deng P, Zhang T, Zhou C, Liang Y, Zhang L, He M, Lu Y, Chen C, Yu Z, Zhou Z. KIF5A-dependent Axonal Transport Deficiency Disrupts Autophagic Flux in Trimethyltin Chloride-Induced Neurotoxicity. Autophagy (2020) DOI: 10.1080/15548627.2020.1739444

9. Zeng X, Xi Y, Jiang W. Protective roles of flavonoids and flavonoid-rich plant extracts against urolithiasis: A review. Crit Rev Food Sci Nutr (2019) 59:2125-2135. doi: 10.1080/10408398.2018.1439880.

10. Wang X, Xi Y, Zeng X, Zhao H, Cao J, Jiang W. Effects of chlorogenic acid against aluminum neurotoxicity in ICR mice through chelation and antioxidant actions. Journal of Functional Foods (2017) 40, 365–376.