姓名：张婧婕

出生年月：1984年10月

最高学历学位：博士研究生学历，医学博士学位

职称：副教授

导师类型：硕士生导师

电子邮箱：jingjiezhang@btbu.edu.cn

个人简历

教育经历：

2003年9月至2008年7月，北京大学，基础医学，学士

2008年9月至2012年7月，北京大学，药理学，博士

2010年10月至2012年4月，美国纽约大学，联合培养博士研究生

工作经历：

2012年8月至2014年11月，中国食品工业（集团）公司，工程师

2014年12月至2018年8月，中国食品工业（集团）公司，高级工程师

2018年9月至2021年6月，中国农业科学院，博士后

2021年7月至今，HG0086皇冠，副教授

主要研究领域

食物营养功能评价、功能性食品作用机理研究等

主要学术成果（课题、论文、获奖、专利等）

发表的代表性论文（限10篇）：

1. Yonghui Yu, Jingjie Zhang, Jing Wang, Baoguo Sun. MicroRNAs: The novel mediators for nutrient-modulating biological functions. TRENDS IN FOOD SCIENCE & TECHNOLOGY. 2021, 114: 167-175.

2. Yonghui Yu, Goutom Kumar Gaine, Linyue Zhou, Jingjie Zhang, Jing Wang, Baoguo Sun. The classical and potential novel healthy functions of rice bran protein and its hydrolysates. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION. 2021.

3. Jingjie Zhang, Yonghui Yu, Jing Wang. Protein Nutritional Support: The Classical and Potential New Mechanisms in the Prevention and Therapy of Sarcopenia. Journal of Agricultural and Food Chemistry. 2020, 68: 4098-4108.2.

4. Yonghui Yu, Jingjie Zhang, Jing Wang, Baoguo Sun. The anti-cancer activity and

potential clinical application of rice bran extracts and fermentation products. RSC Advances. 2019, 9: 18060.

5. Ruowen Zhang, Xun Che, Jingjie Zhang, Yang Li, Jingxia Li, Xu Deng, Junlan Zhu, Honglei Jin, Qinshi Zhao, Chuanshu Huang. Cheliensisin A (Chel A) induces apoptosis in human bladder cancer cells by promoting PHLPP2 protein degradation. Oncotarget. 2016 Oct 11;7(41):66689-66699.

6. Junlan Zhu, Jingjie Zhang, Haishan Huang, Jingxia Li, Yonghui Yu, Honglei Jin, Yang Li, Xu Deng, Jimin Gao, Qinshi Zhao, Chuanshu Huang. Crucial role of c-Jun phosphorylation at Ser63/73 mediated by PHLPP protein degradation in the cheliensisin a inhibition of cell transformation. Cancer Prevention Research (Phila). 2014, 7: 1270-1281.

7. Jingjie Zhang, Guangxun Gao, Liang Chen, Jingxia Li, Xu Deng, Qin-shi Zhao, Chuanshu Huang. Hydrogen peroxide/ATR-Chk2 activation mediates p53 protein stabilization and anti-cancer activity of cheliensisin A in human cancer cells. Oncotarget. 2014, 5: 841-852.

8. Jingjie Zhang, Guangxun Gao, Liang Chen, Xu Deng, Jingxia Li, Yonghui Yu, Dongyun Zhang, Fei Li, Min Zhang, Qinshi Zhao, Chuanshu Huang. Cheliensisin A inhibits EGF-induced cell transformation with stabilization of p53 protein via a hydrogen peroxide/Chk1-dependent axis. Cancer Prevention Research (Phila). 2013,6(9):949-958.

9. Jingjie Zhang, Weiming Ouyang, Jingxia Li, Yonghui Yu, Xuejun Li, Chuanshu Huang. Suberoylanilide Hydroxamic Acid (SAHA) Inhibits EGF-induced Cell Transformation via Reduction of cyclin d1 mRNA Stability. Toxicology and Applied Pharmacology. 2012, 263: 218-224.

10. Yan Xu, Jingjie Zhang, Jing Han, Xueyang Pan, Yajun Cao, Hao Guo, Yan Pan, Yu An, Xuejun Li. Curcumin inhibits tumor proliferation induced by neutrophil elastase through the upregulation of α1-antitrypsin in lung cancer. Molecular Oncology. 2012, 6: 405-17.